![]() ![]() We then compare our current understanding of drug-induced changes in neuronal reward circuitry with what is known about the consequences of repeated consumption of highly palatable foods such as high-fat and high-sugar diets. In this article we review the extensive research that has identified several mechanisms by which repeated exposure to drugs of abuse alters neuronal function and increases the motivational incentive to obtain and use these substances. In contrast to the consumption of food, the motivation to use drugs of abuse is mediated only by the reward pathway. In contrast, hedonic or reward-based regulation can override the homeostatic pathway during periods of relative energy abundance by increasing the desire to consume foods that are highly palatable. The homeostatic pathway controls energy balance by increasing the motivation to eat following depletion of energy stores. Food intake is regulated by 2 complementary drives: the homeostatic and hedonic pathways. ![]()
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